Sometimes the neurologist themselves will do it, but very often it’s a tech person in the office that does it.Īnd in either case, either the tech or the neurologist, they don’t understand peripheral nerve anatomy well enough to often even test for certain things. Part of the problem is that often these tests are administered by techs. Transcript: The problem with EMG and nerve conduction studies is that they are notoriously inaccurate or unreliable at identifying peripheral nerve problems. Tollestrup explains, EMG studies are notoriously flawed because the people doing the EMG study lack a fundamental understanding of peripheral nerve anatomy. Isolated sciatic nerves of rats exposed to 5 µg/mL or 20 µg/mL of BDE-85 showed a significant reduction in nerve conduction velocity and compound action potential amplitudes, indicating physiological damage to the sciatic nerves.EMG studies are sometimes thought to be the gold standard to diagnose nerve injuries. The results indicate a significant disruption in the oxidant/antioxidant equilibrium and setting in of oxidative stress. The oxidative stress markers, lipid hydroperoxides, and the activities of antioxidant enzymes, namely superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione-S-transferase (GST), and catalase, in the exposed mice liver and brain tissues showed tissue-specific alterations following intraperitoneal injection of 0.25 mg/kg body weight of BDE-85 for 4 days. This study, therefore, reports the oxidative status and sciatic nerve conduction properties following BDE-85 treatment in rodents.
Although there are some studies on other congeners of PBDEs, there are none on the toxicity potential of this penta-BDE member. BDE-85 is a congener of a class of flame-retardant compounds called polybrominated diphenyl ethers (PBDEs).
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